Investigators and Laboratories Available to T35 Trainees
Characterizing Auditory and Vestibular Function in Individuals with Down Syndrome
Multiple Mentors: Kristen Janky, Gabrielle Merchant, Heather Porter,
Individuals with Down syndrome, caused by trisomy 21, experience high rates of hearing loss, affecting approximately 80% of the population. Despite the critical role of hearing in development, learning, communication, and quality of life, the mechanisms underlying hearing loss in individuals with Down syndrome remain unclear.
To address this gap, we have assembled a multidisciplinary team to investigate auditory and vestibular dysfunction in individuals with DS. In this project, we are conducting comprehensive auditory and vestibular phenotyping in 300 participants with Down syndrome using behavioral and physiologic assessments, while also collecting detailed health histories, including co-occurring conditions and exposure to ototoxic medications.